Ubiquitylation at the crossroads of development and disease

M Rape - Nature reviews Molecular cell biology, 2018 - nature.com
Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Intrinsic control of axon regeneration

Z He, Y Jin - Neuron, 2016 - cell.com
A determinant of axon regeneration is the intrinsic growth ability of injured neurons, which
dictates a battery of injury responses in axons and cell bodies. While some of these …

Neural stem cell transplantation for neurodegenerative diseases

R De Gioia, F Biella, G Citterio, F Rizzo, E Abati… - International journal of …, 2020 - mdpi.com
Neurodegenerative diseases are disabling and fatal neurological disorders that currently
lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a …

Branching out: mechanisms of dendritic arborization

YN Jan, LY Jan - Nature Reviews Neuroscience, 2010 - nature.com
Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …

KLF family members regulate intrinsic axon regeneration ability

DL Moore, MG Blackmore, Y Hu, KH Kaestner, JL Bixby… - Science, 2009 - science.org
Neurons in the central nervous system (CNS) lose their ability to regenerate early in
development, but the underlying mechanisms are unknown. By screening genes …

Bioenergetics and redox adaptations of astrocytes to neuronal activity

JP Bolaños - Journal of neurochemistry, 2016 - Wiley Online Library
Neuronal activity is a high‐energy demanding process recruiting all neural cells that adapt
their metabolism to sustain the energy and redox balance of neurons. During …

Origins, development, and compartmentation of the granule cells of the cerebellum

GG Consalez, D Goldowitz, F Casoni… - Frontiers in neural …, 2021 - frontiersin.org
Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation

A Almeida, D Jimenez-Blasco… - Essays in …, 2023 - portlandpress.com
Astrocytes show unique anatomical, morphological, and metabolic features to take up
substrates from the blood and metabolize them for local delivery to active synapses to …

Cubism and the cell cycle: the many faces of the APC/C

J Pines - Nature reviews Molecular cell biology, 2011 - nature.com
One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …

Neuronal intrinsic mechanisms of axon regeneration

K Liu, A Tedeschi, KK Park, Z He - Annual review of …, 2011 - annualreviews.org
Failure of axon regeneration after central nervous system (CNS) injuries results in
permanent functional deficits. Numerous studies in the past suggested that blocking …