Privileged structures have been widely used as an effective template in medicinal chemistry
for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring …

While the Staudinger reaction has first been described a hundred years ago in 1919, the
ligation reaction became one of the most important and efficient bioconjugation techniques …

Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …

Eukaryotic and prokaryotic organisms possess huge numbers of uncharacterized enzymes.
Selective inhibitors offer powerful probes for assigning functions to enzymes in native …

The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Many Gram‐negative and Gram‐positive bacteria recycle a significant proportion of the
peptidoglycan components of their cell walls during their growth and septation. In many …

Bioconjugation via azide– Staudinger ligation : an overview - Chemical Society Reviews (RSC
Publishing) DOI:10.1039/C0CS00123F Royal Society of Chemistry View PDF VersionPrevious …

Abstract In 1919 the German chemist Hermann Staudinger was the first to describe the
reaction between an azide and a phosphine. It was not until recently, however, that Bertozzi …

The enzymatic hydrolysis of the glycosidic bond continues to gain importance, reflecting the
critically important roles complex glycans play in health and disease as well as the rekindled …

Highlights•Glycosidases carry out many essential functions across all domains of
life.•Activity-based probes can interrogate complex biological samples for glycosidase …