[HTML][HTML] Circular RNAs: Characterization, cellular roles, and applications

CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …

Biogenesis and regulatory roles of circular RNAs

L Yang, JE Wilusz, LL Chen - Annual review of cell and …, 2022 - annualreviews.org
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes
as well as from the processing of cellular housekeeping noncoding RNAs and precursor …

Circular RNA: metabolism, functions and interactions with proteins

WY Zhou, ZR Cai, J Liu, DS Wang, HQ Ju, RH Xu - Molecular cancer, 2020 - Springer
Abstract Circular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules
that are ubiquitous across species ranging from viruses to mammals. Important advances …

The expanding regulatory mechanisms and cellular functions of circular RNAs

LL Chen - Nature reviews Molecular cell biology, 2020 - nature.com
Many protein-coding genes in higher eukaryotes can produce circular RNAs (circRNAs)
through back-splicing of exons. CircRNAs differ from mRNAs in their production, structure …

Targeting mitochondria-located circRNA SCAR alleviates NASH via reducing mROS output

Q Zhao, J Liu, H Deng, R Ma, JY Liao, H Liang, J Hu… - Cell, 2020 - cell.com
Mitochondria, which play central roles in immunometabolic diseases, have their own
genome. However, the functions of mitochondria-located noncoding RNAs are largely …

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

J Xu, Z Wan, M Tang, Z Lin, S Jiang, L Ji, K Gorshkov… - Molecular cancer, 2020 - Springer
Background and aims Accumulating evidence suggests that the primary and acquired
resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple …

METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA

Z Wu, Y Shi, M Lu, M Song, Z Yu, J Wang… - Nucleic acids …, 2020 - academic.oup.com
Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known
epitranscriptional regulatory mechanism affecting central biological processes, but its …

[HTML][HTML] The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer

D Ramesh-Kumar, S Guil - Seminars in Cancer Biology, 2022 - Elsevier
RNA binding proteins that act at the post-transcriptional level display a richness of
mechanisms to modulate the transcriptional output and respond to changing cellular …

RNA methylations in human cancers

X Han, M Wang, YL Zhao, Y Yang, YG Yang - Seminars in cancer biology, 2021 - Elsevier
RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …

Translation of noncoding RNAs and cancer

B Zhou, H Yang, C Yang, Y Bao, S Yang, J Liu, Y Xiao - Cancer letters, 2021 - Elsevier
The human genome contains thousands of noncoding RNAs (ncRNAs), which are thought to
lack open reading frames (ORFs) and cannot be translated. Some ncRNAs reportedly have …