We review here the methods by which a silyl group, incorporated into an organic structure,
has been used in organic synthesis to control stereochemistry, or has been an integral but …

The aldol addition is one of the most important methods for stereoselective construction of
carboncarbon bonds. New and powerful variants of these classical reactions have been …

The directed aldol reaction allows the construction of new carbon–carbon bonds in a regio‐,
diastereo‐, and enantioselective manner. The kinetically controlled, boron‐mediated aldol …

The selective formation of bondings between molecules is one of the major challenges in
organic chemistry, and the so-called aldol reaction is one of the most important for this …

A systematic investigation of the stereoselectivity in Lewis acid-promoted (Mukaiyama) aldol
reactions of achiral unsubstituted enolsilanes and chiral β-hydroxy aldehydes proceeding …

Conspectus Enamine and enol ethers are nucleophilic functional groups that are well known
to most chemists. When enamine or enol ethers are present in natural products, they are …

The asymmetric syntheses of 6-deoxyerythronolide B (1) and oleandolide (2) have been
achieved, each in 18 linear steps. These syntheses demonstrate the utility of chiral β-keto …

Polyether ionophores are complex natural products capable of transporting cations across
biological membranes. Many polyether ionophores possess potent antimicrobial activity and …

A new process is described for metal-catalyzed doubly diastereoselective Mukaiyama aldol
coupling of a chiral tertiary α-amino aldehyde and an achiral silyl enol ether to form …

Lithium hexamethyldisilazide (LiHMDS) in triethylamine (Et3N)/toluene is shown to enolize
acyclic ketones and esters rapidly and with high E/Z selectivity. Mechanistic studies reveal a …