Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

For decades lysophosphatidylcholine (LPC, lysolecithin) has been used to induce
demyelination, without a clear understanding of its mechanisms. LPC is an endogenous …

Abstract Enolase 1 (ENO1) is a glycolytic enzyme that plays essential roles in various
pathological activities including cancer development. However, the mechanisms underlying …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

Lysophosphatidylcholine (LPC) and lysophosphatidic acid (LPA), the most prominent
lysoglycerophospholipids, are emerging as a novel class of inflammatory lipids, joining …

Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by
excess iron and insufficiency in the glutathione antioxidant pathway. Oxidative stress is …

Phospholipase A 2 s generate lipid mediators that constitute an important component of the
integrated response of macrophages to stimuli of the innate immune response. Because …

Abstract Phospholipases A2 (PLA2s) belong to a superfamily of enzymes responsible for
hydrolyzing the sn-2 fatty acids of membrane phospholipids. These enzymes are known to …

Phospholipases A2 (PLA2) are a diverse group of enzymes that hydrolyze membrane
phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is metabolized …