Abstract Type 2 diabetes (T2D) is linked to the apoptosis of insulin-producing β-cells due to
the aberrant fibrillation of the human islet amyloid polypeptide (hIAPP or amylin) to cytotoxic …

Monitoring early-stage β-amyloid (Aβ) dimerization is a formidable challenge for
understanding neurological diseases. We compared β-sheet formation and histidine site …

Controlling protein misfolding and accumulation in neurodegeneration is a challenge in
chemical neuroscience. The application of appropriate electric fields (EFs) can be a …

Our prior studies have illustrated that the uracil ruthenium (II) diimino complex,[Ru (H 3 ucp)
Cl (PPh 3)](1)(H 4 ucp= 2, 6-bis-((6-amino-1, 3-dimethyluracilimino) methylene) pyridine) …

Histidine tautomerism plays a key role in the aggregation of amyloid peptides, which is
important for understanding the origin of Alzheimer's disease as well as its diagnosis and …

Histidine behaviors (including tautomeric behaviors and protonation behaviors) have been
considered as an origin factor in protein folding and misfolding. However, such effects on …

Hundreds of millions of people around the world have been affected by Type 2 diabetes
(T2D) which is a metabolic disorder. Clinical research has revealed T2D as a possible risk …

Abstract Characterization of the conformational alterations involved in monomer misfolding
is essential for elucidating the molecular basis of the initial stage of protein accumulation …