Methotrexate (MTX) is the prototype folate antagonist cytotoxic drug, employed in the
therapy of solid tumors and leukaemias, and recently also as an immunosuppressive agent …

A method involving the semirobotic liquid− liquid extraction (LLE) in deep-well 96-well
plates was developed for the quantitation of the anti-cancer/antiinflammatory drug …

A controlled release delivery system that localizes methotrexate (MTX) in the synovial joint is
needed to treat inflammation in rheumatoid arthritis (RA). The purpose of this work was to …

Methotrexate (MTX) is an anticancer drug that is widely used in a variety of cancers
including primary central nervous system lymphoma. It is also administrated in the treatment …

Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of
tumors and autoimmune diseases. Several automated binding assays are used in clinical …

Methotrexate (MTX) is an anticancer agent that is widely used in a variety of human cancers
including primary central nervous system lymphoma (PCNSL). Important pharmacological …

Background: Prednisone alone or in combination with an immunosuppressive drug is
usually effective in controlling bullous pemphigoid. However, corticosteroids often cause …

A sensitive and simple method for the methotrexate quantification was developed using
aminopterin as internal standard. Methotrexate is an anticancer agent that is widely used in …

A simple, rapid and sensitive reversed-phase high performance liquid chromatography
(HPLC) method has been developed for the determination of methotrexate in human serum …

A rapid liquid chromatography/positive ion electrospray mass spectrometric assay (LC/ESI-
MS) was developed for the quantitation of methotrexate, folinic acid, folic acid and …