Aging and DNA methylation
M Jung, GP Pfeifer - BMC biology, 2015 - Springer
In this Opinion article, we summarize how changes in DNA methylation occur during aging
in mammals and discuss examples of how such events may contribute to the aging process …
in mammals and discuss examples of how such events may contribute to the aging process …
A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging
Over the past three decades, considerable effort has been dedicated to quantifying the pace
of ageing yet identifying the most essential metrics of ageing remains challenging due to …
of ageing yet identifying the most essential metrics of ageing remains challenging due to …
[HTML][HTML] Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging
Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan
improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we …
improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we …
OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …
Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria
C Ubaida-Mohien, A Lyashkov, M Gonzalez-Freire… - Elife, 2019 - elifesciences.org
A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty
in older persons, but the molecular mechanisms of such decline are not understood. Here …
in older persons, but the molecular mechanisms of such decline are not understood. Here …
Skeletal muscle transcriptome in healthy aging
Age-associated changes in gene expression in skeletal muscle of healthy individuals reflect
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …
accumulation of damage and compensatory adaptations to preserve tissue integrity. To …
Association of vision impairment with cognitive decline across multiple domains in older adults
V Varadaraj, B Munoz, JA Deal, Y An… - JAMA network …, 2021 - jamanetwork.com
Importance Associations between visual and global cognitive impairments have been
previously documented, but there is limited research examining these associations between …
previously documented, but there is limited research examining these associations between …
Hibernation slows epigenetic ageing in yellow-bellied marmots
Species that hibernate generally live longer than would be expected based solely on their
body size. Hibernation is characterized by long periods of metabolic suppression (torpor) …
body size. Hibernation is characterized by long periods of metabolic suppression (torpor) …
[HTML][HTML] Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging
N Bobba-Alves, G Sturm, J Lin, SA Ware… - …, 2023 - Elsevier
Stress triggers anticipatory physiological responses that promote survival, a phenomenon
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …
termed allostasis. However, the chronic activation of energy-dependent allostatic responses …
Fatigued, but not frail: perceived fatigability as a marker of impending decline in mobility‐intact older adults
Objectives To evaluate perceived fatigability as a predictor of meaningful functional decline
in non‐mobility‐limited older adults. Design Longitudinal analysis of data from the Baltimore …
in non‐mobility‐limited older adults. Design Longitudinal analysis of data from the Baltimore …