Research progress of targeted therapy regulating Th17/Treg balance in bone immune diseases

X Wang, B Sun, Y Wang, P Gao, J Song… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-
immune diseases. The imbalance between helper (Th17) and regulatory T cells (Tregs) …

Role of IL-34 and its receptors in inflammatory diseases

J Shang, Y Xu, S Pu, X Sun, X Gao - Cytokine, 2023 - Elsevier
In recent years, IL-34 has been widely discussed as a novel cytokine. IL-34 is a pro-
inflammatory cytokine binding four distinct receptors, namely CSF-1R, syndecan-1, PTP-ζ …

The role of lactylation in plasma cells and its impact on rheumatoid arthritis pathogenesis: insights from single-cell RNA sequencing and machine learning

W Fu, T Wang, Y Lu, T Shi, Q Yang - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by
persistent synovitis, systemic inflammation, and autoantibody production. This study aims to …

[HTML][HTML] Bromodomain-Containing 4 Is a Positive Regulator of Interleukin-34 Production in the Gut

E Franzè, F Laudisi, R Frascatani, L Tomassini… - Cells, 2024 - mdpi.com
Experimental evidence suggests that, in the inflamed gut of inflammatory bowel disease
(IBD) patients, interleukin-34 (IL-34) triggers detrimental signaling pathways …

Cut-off value for interleukin-34 as an additional potential inflammatory biomarker for estimation of slow coronary flow risk

M Karasu, HA Bolayır - BMC Cardiovascular Disorders, 2024 - Springer
Background Inflammatory markers may provide insights into the underlying mechanisms of
slow coronary flow (SCF), including subclinical atherosclerosis and endothelial dysfunction …

Serum levels of free light chains and syndecan-1 in patients with rheumatoid arthritis and systemic lupus erythematosus

V Carnazzo, F Gulli, V Basile, R Di Santo… - …, 2024 - academic.oup.com
Objectives Systemic autoimmune rheumatic diseases (SARDs) are characterized by chronic
inflammation. Reliable biomarkers are crucial for diagnosis, monitoring disease progression …

Is there a relationship between CSF Interleukin 34 Level and clinicoradiological activity and IgG index in patients with MS?

ŞF Gökçe, A Bolayır, B Çiğdem - Multiple Sclerosis and Related Disorders, 2024 - Elsevier
Background Multiple sclerosis is an autoimmune, inflammatory, and disabling disease that is
subject to research, with the aspects of its pathogenesis awaiting clarification. It is essential …

Rheumatoid arthritis: a complex tale of autoimmune hypersensitivity

J Heo, S Heo, JR Kang, J Kweon… - Exploration of …, 2024 - explorationpub.com
Rheumatoid arthritis (RA) is a complex autoimmune disorder characterized by a spectrum of
hypersensitivity reactions, encompassing Type II, Type III, and Type IV responses. Firstly, RA …

Spotlight on Syndecan 1 Role in Systemic Autoimmune Rheumatic Diseases: Main Actor or Guest Appearance?

V Carnazzo, F Gulli, V Basile, R Di Santo, B Niccolini… - 2024 - preprints.org
Background: Systemic autoimmune rheumatic diseases (SARDs), including Systemic Lupus
Erythematosus (SLE) and Rheumatoid Arthritis (RA), are characterized by chronic …