Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin,
phenotypic and functional heterogeneity, are the most essential components of the tumor …

Simple Summary Breast cancer is the most common cancer among women. It is estimated
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …

Colorectal cancer (CRC) is among the most common malignancies with limited treatments
other than surgery. The tumor microenvironment (TME) profiling enables the discovery of …

Macrophages play an important role in tissue homeostasis, tissue remodeling, immune
response, and progression of cancer. Consequently, macrophages exhibit significant …

Among all the stromal cells that present in the tumor microenvironment, cancer-associated
fibroblasts (CAFs) are one of the most abundant and critical components of the tumor …

Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and
mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is …

Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-
linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma …

Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture
and function. Growth in most solid tumors is dependent upon remodeling 'stroma', composed …

Simple Summary Cancer-associated fibroblasts (CAFs) are found in the tumor
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …

The view of cancer as a tumor cell-centric disease is now replaced by our understanding of
the interconnection and dependency of tumor stroma. Cancer-associated fibroblasts (CAFs) …