Botulinum toxin as a pain killer: players and actions in antinociception

DW Kim, SK Lee, J Ahnn - Toxins, 2015 - mdpi.com
Botulinum neurotoxins (BoNTs) have been widely used to treat a variety of clinical ailments
associated with pain. The inhibitory action of BoNTs on synaptic vesicle fusion blocks the …

Uptake of clostridial neurotoxins into cells and dissemination

C Connan, MR Popoff - Uptake and Trafficking of Protein Toxins, 2017 - Springer
Clostridial neurotoxins, botulinum neurotoxins (BoNT) and tetanus neurotoxin (TeNT), are
potent toxins, which are responsible for severe neurological diseases in man and animals …

Endocytosis of corn oil-caseinate emulsions in vitro: impacts of droplet sizes

Y Fan, Y Zhang, W Yokoyama, J Yi - Nanomaterials, 2017 - mdpi.com
The relative uptake and mechanisms of lipid-based emulsions of three different particle
diameters by Caco-2 cells were studied. The corn oil-sodium caseinate emulsions showed …

Translocation and dissemination of botulinum neurotoxin from the intestinal tract

Y Fujinaga, MR Popoff - Toxicon, 2018 - Elsevier
Botulinum neurotoxins (BoNTs) are potent toxins which induce flaccid paralysis by inhibiting
the release of acetylcholine at the neuromuscular junctions. They associate with non-toxic …

Role of critical elements in botulinum neurotoxin complex in toxin routing across intestinal and bronchial barriers

KJ Ghosal, K Patel, BR Singh, ML Hale - PLoS One, 2018 - journals.plos.org
The highly potent botulinum neurotoxin serotype A (BoNT/A) inhibits neurotransmitter
release at neuromuscular junctions resulting in flaccid muscle paralysis, respiratory arrest …

Intellectual functioning in offspring of parents with bipolar disorder: a review of the literature

B Klimes-Dougan, J Jeong, KP Kennedy, TA Allen - Brain Sciences, 2017 - mdpi.com
Impaired intellectual functioning is an important risk factor for the emergence of severe
mental illness. Unlike many other forms of mental disorder however, the association …

Comparative pharmacodynamics study of 3 different botulinum toxin type A preparations in mice

S Kwak, W Kang, CH Rhee, GH Yang… - Dermatologic …, 2020 - journals.lww.com
BACKGROUND A new complexing protein-free botulinum toxin Type A (CBoNT) with the
same mechanism of action as the botulinum toxin complex onabotulinumtoxinA (OBoNT) …

Probiotic microorganisms inhibit epithelial cell internalization of botulinum neurotoxin serotype A

TI Lam, CC Tam, LH Stanker, LW Cheng - Toxins, 2016 - mdpi.com
Botulinum neurotoxins (BoNTs) are some of the most poisonous natural toxins known to
man and are threats to public health and safety. Previous work from our laboratory showed …

Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall

C Connan, C Varela‐Chavez, C Mazuet… - Cellular …, 2016 - Wiley Online Library
Botulinum neurotoxins (BoNTs) are responsible for severe flaccid paralysis (botulism), which
in most cases enter the organism via the digestive tract and then disseminate into the blood …

Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption

S Amatsu, T Matsumura, M Yutani… - Microbiology and …, 2018 - Wiley Online Library
Hemagglutinin (HA) is one of the components of botulinum neurotoxin (BoNT) complexes
and it promotes the absorption of BoNT through the intestinal epithelium by at least two …