Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

Rationale: Microglia play a critical role in modulating cell death and neurobehavioral
recovery in response to brain injury either by direct cell-cell interaction or indirect secretion …

The intrinsic ability of neurogenesis after stroke has been proven weak, which results in
insufficient repair of injury in the nerve system. Recent studies suggest multiple microRNAs …

Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

Grafted mesenchymal stem cells (MSCs) yield neuroprotection in preclinical stroke models
by secreting extracellular vesicles (EVs). The neuroprotective cargo of EVs, however, has …

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Ischemic stroke is a cerebrovascular disease normally caused by interrupted blood supply to
the brain. Ischemia would initiate the cascade reaction consisted of multiple biochemical …

MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124
displays specific temporal and spatial profiles in various cell and tissue types and affects a …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …