Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …

The unique class of heavy chain–only antibodies, present in Camelidae, can be shrunk to
just the variable region of the heavy chain to yield VHHs, also called nanobodies. About one …

Reagents that bind tightly and specifically to biomolecules of interest remain essential in the
exploration of biology and in their ultimate application to medicine. Besides ligands for …

Vesicular stomatitis virus (VSV) is a negative-strand RNA virus with a non-segmented
genome, closely related to rabies virus. Both have characteristic bullet-like shapes. We …

Defective interfering particles (DIPs), derived naturally from viral particles, are not able to
replicate on their own. Several studies indicate that DIPs exert antiviral effects via multiple …

Multivalent antibody constructs have a broad range of clinical and biotechnological
applications. Nanobodies are especially useful as components for multivalent constructs as …

Measles virus genome encapsidation is essential for viral replication and is controlled by the
intrinsically disordered phosphoprotein (P) maintaining the nucleoprotein in a monomeric …

The measles virus replication complex represents a potentially important, but as yet
relatively unexplored target for viral inhibition. Little is known about the molecular …

A substantial fraction of eukaryotic proteins is folded and modified in the endoplasmic
reticulum (ER) prior to export and secretion. Proteins that enter the ER but fail to fold …

To interfere with cell function, many scientists rely on methods that target DNA or RNA due to
the ease with which they can be applied. Proteins are usually the final executors of function …