Several combinatorial methods have been developed to create focused or diverse chemical
libraries with a wide range of linear or macrocyclic chemical molecules: peptides, non …

This article summarizes the evolution of the screening deck at the Novartis Institutes for
BioMedical Research (NIBR). Historically, the screening deck was an assembly of all …

DNA-encoded chemical libraries (DECLs) are collections of organic compounds that are
individually linked to different oligonucleotides, serving as amplifiable identification …

Highlights•High-quality compound collections are a main determinant of drug discovery
success.•Generation of relevant collections is a significant challenge for any …

Highlights•A critical assessment of 16 million commercially available compounds.•A
comparison of vendors' offerings.•How the offerings have evolved to meet modern …

Iterative screening is a process in which screening is done in batches, with each batch filled
by using machine learning to select the most promising compounds from the library based …

DNA-encoded library (DEL) screens have emerged as a powerful hit-finding tool for a
number of biological targets. In this Innovations article, we review published hit-to-lead …

Over the past few decades, hit identification has been greatly facilitated by advances in high-
throughput and fragment-based screenings. One major hurdle remaining in drug discovery …

While mechanisms of cytotoxicity and cytostaticity have been studied extensively from the
biological side, relatively little is currently understood regarding areas of chemical space …

Challenged by ageing infrastructure and increasingly demanding screening cascades,
AstraZeneca High Throughput Screening department has developed advanced automation …