Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin)
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical age at …
Idiopathic hypersomnia
M Billiard, K Sonka - Sleep medicine reviews, 2016 - Elsevier
Idiopathic hypersomnia continues to evolve from the concept of “sleep drunkenness”
introduced by Bedrich Roth in Prague in 1956 and the description of idiopathic hypersomnia …
introduced by Bedrich Roth in Prague in 1956 and the description of idiopathic hypersomnia …
Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China
Objective: Narcolepsy is caused by the loss of hypocretin/orexin neurons in the
hypothalamus, which is likely the result of an autoimmune process. Recently, concern has …
hypothalamus, which is likely the result of an autoimmune process. Recently, concern has …
Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland
M Partinen, O Saarenpää-Heikkilä, I Ilveskoski… - PloS one, 2012 - journals.plos.org
Background Narcolepsy is a rare neurological sleep disorder especially in children who are
younger than 10 years. In the beginning of 2010, an exceptionally large number of Finnish …
younger than 10 years. In the beginning of 2010, an exceptionally large number of Finnish …
[HTML][HTML] The autoimmune basis of narcolepsy
J Mahlios, AK De la Herrán-Arita, E Mignot - Current opinion in …, 2013 - Elsevier
Highlights•Narcolepsy is caused by the loss of hypocretin-producing neurons in the
brain.•HLA DQB1* 06: 02 association suggests an autoimmune basis for narcolepsy.• …
brain.•HLA DQB1* 06: 02 association suggests an autoimmune basis for narcolepsy.• …
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza …
Previous studies in narcolepsy, an autoimmune disorder affecting hypocretin (orexin)
neurons and recently associated with H1N1 influenza, have demonstrated significant …
neurons and recently associated with H1N1 influenza, have demonstrated significant …
Connecting the dots: An updated review of the role of autoimmunity in narcolepsy and emerging immunotherapeutic approaches
Abstract Background Narcolepsy type 1 (NT1) is a chronic disorder characterized by
pathological daytime sleepiness and cataplexy due to the disappearance of orexin …
pathological daytime sleepiness and cataplexy due to the disappearance of orexin …
Epidemiology and pathophysiology of childhood narcolepsy
TJ Dye, N Gurbani, N Simakajornboon - Paediatric Respiratory Reviews, 2018 - Elsevier
It is now recognized that there are two types of narcolepsy. Narcolepsy type I or Narcolepsy
with cataplexy is caused by the loss of hypocretin or orexin neurons. Narcolepsy type II or …
with cataplexy is caused by the loss of hypocretin or orexin neurons. Narcolepsy type II or …
Autoimmunity in narcolepsy
Narcolepsy is a severe sleep disorder, in which neurons producing orexin/hypocretin in the
hypothalamus are destroyed. The core symptoms of narcolepsy are debilitating, extreme …
hypothalamus are destroyed. The core symptoms of narcolepsy are debilitating, extreme …
HLA‐DQ association and allele competition in Chinese narcolepsy
F Han, L Lin, J Li, SX Dong, P An, L Zhao… - Tissue …, 2012 - Wiley Online Library
In Japanese, Koreans and Caucasians, narcolepsy/hypocretin deficiency is tightly
associated with the DRB1* 15: 01‐DQA1* 01: 02‐DQB1* 06: 02 haplotype. Studies in …
associated with the DRB1* 15: 01‐DQA1* 01: 02‐DQB1* 06: 02 haplotype. Studies in …