A whole-genome reference panel of 14,393 individuals for East Asian populations accelerates discovery of rare functional variants

J Choi, S Kim, J Kim, HY Son, SK Yoo, CU Kim… - Science …, 2023 - science.org
Underrepresentation of non-European (EUR) populations hinders growth of global precision
medicine. Resources such as imputation reference panels that match the study population …

[HTML][HTML] African population history: an ancient DNA perspective

M Vicente, CM Schlebusch - Current Opinion in Genetics & Development, 2020 - Elsevier
The history of human populations in Africa is complex and includes various demographic
events that influenced patterns of genetic variation across the continent. Through genetic …

Genomic signatures of sex-biased demography: progress and prospects

TH Webster, MAW Sayres - Current opinion in genetics & development, 2016 - Elsevier
Sex-biased demographic events have played a crucial role in shaping human history. Many
of these processes affect genetic variation and can therefore leave detectable signatures in …

[HTML][HTML] Whole-genome-sequence-based haplotypes reveal single origin of the sickle allele during the holocene wet phase

D Shriner, CN Rotimi - The American Journal of Human Genetics, 2018 - cell.com
Five classical designations of sickle haplotypes are made on the basis of the presence or
absence of restriction sites and are named after the ethno-linguistic groups or geographic …

Qatar genome: Insights on genomics from the Middle East

H Mbarek, G Devadoss Gandhi, S Selvaraj… - Human …, 2022 - Wiley Online Library
Despite recent biomedical breakthroughs and large genomic studies growing momentum,
the Middle Eastern population, home to over 400 million people, is underrepresented in the …

The Qatar genome: a population-specific tool for precision medicine in the Middle East

KA Fakhro, MR Staudt, MD Ramstetter… - Human genome …, 2016 - nature.com
Reaching the full potential of precision medicine depends on the quality of personalized
genome interpretation. In order to facilitate precision medicine in regions of the Middle East …

Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes

RM Razali, J Rodriguez-Flores, M Ghorbani… - Nature …, 2021 - nature.com
Arab populations are largely understudied, notably their genetic structure and history. Here
we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive …

The genomic history of the Middle East

MA Almarri, M Haber, RA Lootah, P Hallast, S Al Turki… - Cell, 2021 - cell.com
Summary The Middle East region is important to understand human evolution and
migrations but is underrepresented in genomic studies. Here, we generated 137 high …

[HTML][HTML] Distinct genetic variation and heterogeneity of the Iranian population

Z Mehrjoo, Z Fattahi, M Beheshtian, M Mohseni… - PLoS …, 2019 - journals.plos.org
Iran, despite its size, geographic location and past cultural influence, has largely been a
blind spot for human population genetic studies. With only sparse genetic information on the …

Between Lake Baikal and the Baltic Sea: genomic history of the gateway to Europe

P Triska, N Chekanov, V Stepanov, EK Khusnutdinova… - BMC genetics, 2017 - Springer
Background The history of human populations occupying the plains and mountain ridges
separating Europe from Asia has been eventful, as these natural obstacles were crossed …