US FDA approved drugs from 2015–June 2020: a perspective
In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors
N Liu, H Xu, Q Sun, X Yu, W Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …
Natural compounds with xanthine oxidase inhibitory activity: A review
A Mehmood, M Ishaq, L Zhao, B Safdar… - Chemical biology & …, 2019 - Wiley Online Library
Hyperuricemia (HUA), a disease due to an elevation of body uric acid level and responsible
for various diseases such as gout, cardiovascular disorders, and renal failure, is a major …
for various diseases such as gout, cardiovascular disorders, and renal failure, is a major …
Mechanism of flavonoids inhibiting xanthine oxidase and alleviating hyperuricemia from structure–activity relationship and animal experiments: A review
H Xue, M Xu, D Gong, G Zhang - Food Frontiers, 2023 - Wiley Online Library
Hyperuricemia (HUA) is a metabolic disease caused by excessive uric acid in patients.
Flavonoids have attracted extensive attention due to their safety, effectiveness, and little side …
Flavonoids have attracted extensive attention due to their safety, effectiveness, and little side …
Novel reversible inhibitors of xanthine oxidase targeting the active site of the enzyme
Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine
and then to uric acid, while simultaneously producing reactive oxygen species. Altered …
and then to uric acid, while simultaneously producing reactive oxygen species. Altered …
Xanthine oxidase inhibitors: patent landscape and clinical development (2015–2020)
Introduction Xanthine oxidase (XO) is a molybdoflavoprotein that catalyzes the oxidative
hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction …
hydroxylation of purines to produce uric acid and reactive oxygen species. These reaction …
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions
SP Rendić, RD Crouch, FP Guengerich - Archives of Toxicology, 2022 - Springer
This is an overview of the metabolic reactions of drugs, natural products, physiological
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
compounds, and other (general) chemicals catalyzed by flavin monooxygenase (FMO) …
Computational characterization of the inhibition mechanism of xanthine oxidoreductase by topiroxostat
Xanthine oxidase (XO) is a member of the molybdopterin-containing enzyme family. It
interconverts xanthine to uric acid as the last step of purine catabolism in the human body …
interconverts xanthine to uric acid as the last step of purine catabolism in the human body …
Novel xanthine oxidase inhibitory peptides derived from whey protein: identification, in vitro inhibition mechanism and in vivo activity validation
X Qi, H Chen, K Guan, Y Sun, R Wang, Q Li, Y Ma - Bioorganic Chemistry, 2022 - Elsevier
As the development of hyperuricemia (HUA) and gout continues to accelerate worldwide,
there is increasing interest in the use of xanthine oxidase (XO) inhibitors as therapeutic …
there is increasing interest in the use of xanthine oxidase (XO) inhibitors as therapeutic …
Coumarin derivatives as promising xanthine oxidase inhibitors
Xanthine oxidase (XO) is an interesting target for the synergic treatment of several diseases.
Coumarin scaffold plays an important role in the design of efficient and potent inhibitors. In …
Coumarin scaffold plays an important role in the design of efficient and potent inhibitors. In …