Von Willebrand disease (VWD) is a bleeding disorder that is mainly caused by mutations in
the multimeric protein von Willebrand factor (VWF). These mutations may lead to …

Von Willebrand disease (VWD) is the most common inherited bleeding disorder but its
diagnosis can be challenging due to the heterogeneity of the disease. VWD is mainly …

Background Endothelial colony forming cells (ECFCs) derived from peripheral blood can be
used to analyze the pathophysiology of vascular diseases ex vivo. However, heterogeneity …

Summary Background Endothelial von Willebrand factor (VWF) inhibits angiogenesis.
Accordingly, blood outgrowth endothelial cells (BOECs) isolated from von Willebrand …

Copy number variation (CNV) is known to cause all von Willebrand disease (VWD) types,
although the associated pathogenic mechanisms involved have not been extensively …

Von Willebrand factor (VWF) plays an essential role in primary hemostasis and is exclusively
synthesized and stored in endothelial cells and megakaryocytes. Upon vascular injury, VWF …

The fifth Åland Island meeting on von Willebrand disease (VWD) was held on the Åland
Islands, Finland, from 22 to 24 September 2016—90 years after the first case of VWD was …

Von Willebrand disease (VWD), the most prevalent congenital bleeding disorder, arises from
deficiencies in quantity or quality of von Willebrand factor (VWF). The quantitative …

The formation of hemostatic plugs at sites of vascular injury crucially involves the multimeric
glycoprotein von Willebrand factor (VWF). VWF multimers are linear chains of N-terminally …

O Fator de von Willebrand (FVW) é uma proteína envolvida na hemostasia, responsável por
mediar a adesão e agregação plaquetára em eventos de lesão vascular. Essa proteína é …