The roles of histone deacetylases and their inhibitors in cancer therapy

G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Targeting histone deacetylases for cancer therapy: Trends and challenges

T Liang, F Wang, RM Elhassan, Y Cheng… - … Pharmaceutica Sinica B, 2023 - Elsevier
Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …

Characterization of histone deacetylase mechanisms in cancer development

R Hai, L He, G Shu, G Yin - Frontiers in Oncology, 2021 - frontiersin.org
Over decades of studies, accumulating evidence has suggested that epigenetic
dysregulation is a hallmark of tumours. Post-translational modifications of histones are …

CUL4B functions as a tumor suppressor in KRAS-driven lung tumors by inhibiting the recruitment of myeloid-derived suppressor cells

X Liu, F Tian, J Cui, L Gong, L Xiang, B Fan, S Liu… - Oncogene, 2023 - nature.com
Lung cancer is the leading cause of cancer-related death worldwide. KRAS mutations are
the most common oncogenic alterations found in lung cancer. Unfortunately, treating KRAS …

[HTML][HTML] Nebulized inhalation of LPAE-HDAC10 inhibits acetylation-mediated ROS/NF-κB pathway for silicosis treatment

Y Tian, H Shi, D Zhang, C Wang, F Zhao, L Li… - Journal of Controlled …, 2023 - Elsevier
Silicosis is a serious silica-induced respiratory disease for which there is currently no
effective treatment. Irreversible pulmonary fibrosis caused by persistent inflammation is the …

[HTML][HTML] The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation

Y Zhong, T Huang, J Huang, J Quan, G Su, Z Xiong… - Theranostics, 2023 - ncbi.nlm.nih.gov
Background: Perturbation of macrophage homeostasis is one of the key mechanisms of
airway inflammation in asthma. However, the exact mechanisms remain poorly understood …

Differential molecular mechanistic behavior of HDACs in cancer progression

T Singh, P Kaur, P Singh, S Singh, A Munshi - Medical Oncology, 2022 - Springer
Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms
normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors …

The role of protein acetylation in carcinogenesis and targeted drug discovery

J Yang, C Song, X Zhan - Frontiers in Endocrinology, 2022 - frontiersin.org
Protein acetylation is a reversible post-translational modification, and is involved in many
biological processes in cells, such as transcriptional regulation, DNA damage repair, and …

Aza-SAHA derivatives are selective histone deacetylase 10 chemical probes that inhibit polyamine deacetylation and phenocopy HDAC10 knockout

RR Steimbach, CJ Herbst-Gervasoni… - Journal of the …, 2022 - ACS Publications
We report the first well-characterized selective chemical probe for histone deacetylase 10
(HDAC10) with unprecedented selectivity over other HDAC isozymes. HDAC10 …

Protein acetylation at the interface of genetics, epigenetics and environment in cancer

M Harachi, K Masui, WK Cavenee, PS Mischel… - Metabolites, 2021 - mdpi.com
Metabolic reprogramming is an emerging hallmark of cancer and is driven by abnormalities
of oncogenes and tumor suppressors. Accelerated metabolism causes cancer cell …