Identification and consequences of miRNA–target interactions—beyond repression of gene expression
Comparative genomics analyses and high-throughput experimental studies indicate that a
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …
Molecular evolution and functional modification of plant miRNAs with CRISPR
Gene editing using clustered regularly interspaced short palindromic repeat/CRISPR-
associated proteins (CRISPR/Cas) has revolutionized biotechnology and provides genetic …
associated proteins (CRISPR/Cas) has revolutionized biotechnology and provides genetic …
Predicting effective microRNA target sites in mammalian mRNAs
MicroRNA targets are often recognized through pairing between the miRNA seed region
and complementary sites within target mRNAs, but not all of these canonical sites are …
and complementary sites within target mRNAs, but not all of these canonical sites are …
[HTML][HTML] miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
Abstract microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO)
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
[PDF][PDF] Global analyses of the effect of different cellular contexts on microRNA targeting
MicroRNA (miRNA) regulation clearly impacts animal development, but the extent to which
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
development—with its resulting diversity of cellular contexts—impacts miRNA regulation is …
[PDF][PDF] Unambiguous identification of miRNA: target site interactions by different types of ligation reactions
S Grosswendt, A Filipchyk, M Manzano, F Klironomos… - Molecular cell, 2014 - cell.com
To exert regulatory function, miRNAs guide Argonaute (AGO) proteins to partially
complementary sites on target RNAs. Crosslinking and immunoprecipitation (CLIP) assays …
complementary sites on target RNAs. Crosslinking and immunoprecipitation (CLIP) assays …
[HTML][HTML] MicroRNA: dynamic regulators of macrophage polarization and plasticity
JB Self-Fordham, AR Naqvi, JR Uttamani… - Frontiers in …, 2017 - frontiersin.org
The ability of a healthy immune system to clear the plethora of antigens it encounters
incessantly relies on the enormous plasticity displayed by the comprising cell types …
incessantly relies on the enormous plasticity displayed by the comprising cell types …
General rules for functional microRNA targeting
The functional rules for microRNA (miRNA) targeting remain controversial despite their
biological importance because only a small fraction of distinct interactions, called site types …
biological importance because only a small fraction of distinct interactions, called site types …
[HTML][HTML] Predicting microRNA targeting efficacy in Drosophila
Background MicroRNAs (miRNAs) are short regulatory RNAs that derive from hairpin
precursors. Important for understanding the functional roles of miRNAs is the ability to …
precursors. Important for understanding the functional roles of miRNAs is the ability to …
[HTML][HTML] EBV and apoptosis: the viral master regulator of cell fate?
L Fitzsimmons, GL Kelly - Viruses, 2017 - mdpi.com
Epstein–Barr virus (EBV) was first discovered in cells from a patient with Burkitt lymphoma
(BL), and is now known to be a contributory factor in 1–2% of all cancers, for which there are …
(BL), and is now known to be a contributory factor in 1–2% of all cancers, for which there are …