Autoimmune subepidermal blistering diseases of the skin and mucosae constitute a large
group of sometimes devastating diseases, encompassing bullous pemphigoid, gestational …

Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …

The major histocompatibility complex (MHC) region is strongly associated with multiple
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …

The contribution of genetic inheritance in multiple sclerosis was established early on.
Although multiple sclerosis is not a Mendelian disease, its incidence and prevalence is …

Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system
commonly affecting young adults. Pathologically, there are patches of inflammation …

An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an
association with the HLA-DRB1* 1501-DQB1* 0602 haplotype has been repeatedly …

To date, more than a dozen studies have investigated the role of HLA genes in determining
clinical course and disease severity in multiple sclerosis (MS); in each of these studies …

An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA)
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …

The human leukocyte antigen (HLA) DRB1* 1501 has been consistently associated with
multiple sclerosis (MS) in nearly all populations tested. This points to a specific antigen …

There is evidence that the clinical course of multiple sclerosis is age related. The present
study evaluated the relationship between age and rate of disability progression in a large …