Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Cognitive impairment in multiple sclerosis with regards to disease duration and clinical phenotypes

B Brochet, A Ruet - Frontiers in neurology, 2019 - frontiersin.org
The relationships between cognitive impairment that exist during the clinical course of
multiple sclerosis (MS) remain poorly described. The effect of disease duration has been …

Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?

F Grussu, T Schneider, C Tur, RL Yates… - Annals of clinical …, 2017 - Wiley Online Library
Objective Conventional magnetic resonance imaging (MRI) of the multiple sclerosis spinal
cord is limited by low specificity regarding the underlying pathological processes, and new …

Assessment and impact of cognitive impairment in multiple sclerosis: an overview

MÁ Macías Islas, E Ciampi - Biomedicines, 2019 - mdpi.com
Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present
early in the course of the disease and has an impact on a patient's employability, social …

Reduced neurite density in the brain and cervical spinal cord in relapsing–remitting multiple sclerosis: A NODDI study

S Collorone, N Cawley, F Grussu… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Background: Multiple sclerosis (MS) affects both brain and spinal cord. However, studies of
the neuraxis with advanced magnetic resonance imaging (MRI) are rare because of long …

Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis

Z Liu, M Pardini, Ö Yaldizli, V Sethi, N Muhlert… - Brain, 2015 - academic.oup.com
In multiple sclerosis, there is increasing evidence that demyelination, and neuronal damage
occurs preferentially in cortical grey matter next to the outer surface of the brain. It has been …

An abnormal periventricular magnetization transfer ratio gradient occurs early in multiple sclerosis

JWL Brown, M Pardini, WJ Brownlee, K Fernando… - Brain, 2017 - academic.oup.com
In established multiple sclerosis, tissue abnormality—as assessed using magnetization
transfer ratio—increases close to the lateral ventricles. We aimed to determine whether or …

Pedunculopontine nucleus microstructure predicts postural and gait symptoms in Parkinson's disease

CE Craig, NJ Jenkinson, JS Brittain… - Movement …, 2020 - Wiley Online Library
Background There is an urgent need to identify individuals at risk of postural instability and
gait difficulties, and the resulting propensity for falls, in Parkinson's disease. Objectives …

[PDF][PDF] Cognitive functions and social cognition in multiple sclerosis: An overview

A Giazkoulidou, L Messinis, G Nasios - Hell J Nucl Med, 2019 - researchgate.net
Cognitive functions and social cognition in multiple sclerosis: An overview Page 1 Brief Review
Cognitive functions and social cognition in multiple sclerosis: An overview Aikaterini …

Motor network efficiency and disability in multiple sclerosis

M Pardini, Ö Yaldizli, V Sethi, N Muhlert, Z Liu… - Neurology, 2015 - AAN Enterprises
Objective: To develop a composite MRI-based measure of motor network integrity, and
determine if it explains disability better than conventional MRI measures in patients with …