Background Several studies have suggested genetic variants associated with
acetaminophen induced liver injury (DILI) following overdose. Genetic variation associated …

In Peru, 29 292 people were diagnosed with tuberculosis in 2022. Although tuberculosis
treatments are effective, 3.4%–13% are associated with significant adverse drug reactions …

In Peru, 24,581 people were diagnosed with tuberculosis (TB) in 2020. Although TB
treatments are effective, 3.4–13% are associated with significant adverse drug reactions …

Background Rifampicin, a key drug against tuberculosis (TB), displays wide between-patient
pharmacokinetics variability and concentration-dependent antimicrobial effect. We …

Abstract Background In Peru, 32,970 people were diagnosed with tuberculosis (TB) in 2019.
Although TB treatment is effective, 3.4%–13% is associated with significant adverse drug …

The process of inhabiting the Americas by ancestral native American populations involved
many individuals settling in the Peruvian Andes and Amazonian regions. Due to Latin …

目的通过两点采样法评估NAT2 酶的基因型与异烟肼的乙酰化率, 肝损害之间的关系.
方法选取口服异烟肼达到稳态的患者共57 例, 分别于服药后2, 4 h 采取末梢血样 …

Objective To study the clinical significance of flow CD161 in HIV with tuberculosis infection,
and compare the differences between different detection methods. Methods The expression …

Tuberculosis is a significant healthcare burden, especially in the developing world. Current
first-line therapies for tuberculosis treatment (isoniazid, pyrazinamide, rifampicin, and …

As populações são marcadas por uma alta variabilidade genética entre os indivíduos,
sendo que essa heterogeneidade pode influir diretamente sobre a eficácia dos fármacos e …