Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

The regulation of telomere length in mammals is crucial for chromosome end-capping and
thus for maintaining genome stability and cellular lifespan. This process requires …

Telomerase is a ribonucleoprotein complex, the catalytic core of which includes the
telomerase reverse transcriptase (TERT) and the non-coding human telomerase RNA (hTR) …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

It has been known for decades that telomerase extends the 3′ end of linear eukaryotic
chromosomes and dictates the telomeric repeat sequence based on the template in its RNA …

There has been mounting evidence of a causal role for telomere dysfunction in a number of
degenerative disorders. Their manifestations encompass common disease states such as …

The mammalian DNA polymerase-α–primase (Polα–primase) complex is essential for DNA
metabolism, providing the de novo RNA–DNA primer for several DNA replication pathways …

Abstract 53BP1 is an enigmatic DNA damage response factor that gained prominence
because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient …

The lengths of human telomeres, which protect chromosome ends from degradation and
end fusions,, are crucial determinants of cell lifespan. During embryogenesis and in cancer …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …