For decades, HDL and HDL-cholesterol (HDL-C) levels were viewed as synonymous, and
modulation of HDL-C levels by drug therapy held great promise for the prevention and …

Cardiovascular diseases (CVDs) have become the leading global cause of mortality,
prompting a heightened focus on identifying precise indicators for their assessment and …

Background: Insulin resistance (IR) can precede the dysglycemic states of prediabetes and
type 2 diabetes mellitus (T2DM) by a number of years and is an early marker of risk for …

The pleiotropic functions of circulating high density lipoprotein (HDL) on peripheral vascular
health are well established. HDL plays a pivotal role in reverse cholesterol transport and is …

Novel plasma metabolite patterns reflective of improved metabolic health (insulin sensitivity,
fitness, reduced body weight) were identified before and after a 14–17 wk weight loss and …

Comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry
(GC× GC–TOFMS) was applied in the quantification and identification of organic compounds …

The “HDL hypothesis” which suggested that an elevation in HDL cholesterol (HDL-C) levels
by drugs or by life style changes should be paralleled by a decrease in the risk for …

Nonalcoholic steatohepatitis (NASH) is a fatty liver disorder that could be improved with
extra virgin olive oil (EVOO) supplementation in diet. We propose the monitoring, in whole …

Rationale Lipoproteins belong to the most commonly measured clinical biochemical
parameters. Lipidomics is an orthogonal approach and aims to profile the individual lipid …

Miniaturization of analytical instrumentation is often suggested to be one of the most
promising approaches to rise to the challenge of high-throughput screening. In this chapter …