Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies
Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …
[HTML][HTML] Acute sarcopenia secondary to hospitalisation-an emerging condition affecting older adults
There has been increasing interest and research into sarcopenia in community-dwelling
older adults since the European Working Group on Sarcopenia in Older People (EWGSOP) …
older adults since the European Working Group on Sarcopenia in Older People (EWGSOP) …
Impact of sedentarism due to the COVID-19 home confinement on neuromuscular, cardiovascular and metabolic health: Physiological and pathophysiological …
The COVID-19 pandemic is an unprecedented health crisis as entire populations have been
asked to self-isolate and live in home-confinement for several weeks to months, which in …
asked to self-isolate and live in home-confinement for several weeks to months, which in …
COVID-19 is associated with clinically significant weight loss and risk of malnutrition, independent of hospitalisation: a post-hoc analysis of a prospective cohort study
L Di Filippo, R De Lorenzo, M D'Amico, V Sofia… - Clinical Nutrition, 2021 - Elsevier
Background & aims Coronavirus disease 2019 (COVID-19) may associate with clinical
manifestations, ranging from alterations in smell and taste to severe respiratory distress …
manifestations, ranging from alterations in smell and taste to severe respiratory distress …
Do patients with COVID-19 benefit from rehabilitation? Functional outcomes of the first 100 patients in a COVID-19 rehabilitation unit
V Piquet, C Luczak, F Seiler, J Monaury… - Archives of Physical …, 2021 - Elsevier
Objective To determine the benefits associated with brief inpatient rehabilitation for
coronavirus 2019 (COVID-19) patients. Design Retrospective chart review. Setting A newly …
coronavirus 2019 (COVID-19) patients. Design Retrospective chart review. Setting A newly …
Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans
Key points Few days of unloading are sufficient to induce a decline of skeletal muscle mass
and function; notably, contractile force is lost at a faster rate than muscle mass. The reasons …
and function; notably, contractile force is lost at a faster rate than muscle mass. The reasons …
Hearing of Otof-deficient mice restored by trans-splicing of N- and C-terminal otoferlin
H Tang, H Wang, S Wang, SW Hu, J Lv, M Xun, K Gao… - Human Genetics, 2023 - Springer
Mutations to the OTOF gene are among the most common reasons for auditory neuropathy.
Although cochlear implants are often effective in restoring sound transduction, there are …
Although cochlear implants are often effective in restoring sound transduction, there are …
Sedentary behavior and the biological hallmarks of aging
J Raffin, P de Souto Barreto, AP Le Traon… - Ageing Research …, 2023 - Elsevier
While the benefits of physical exercise for a healthy aging are well-recognized, a growing
body of evidence shows that sedentary behavior has deleterious health effects …
body of evidence shows that sedentary behavior has deleterious health effects …
Starring or supporting role? Satellite cells and skeletal muscle fiber size regulation
Recent loss-of-function studies show that satellite cell depletion does not promote
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …
sarcopenia or unloading-induced atrophy, and does not prevent regrowth. Although …
Defining anabolic resistance: implications for delivery of clinical care nutrition
RW Morton, DA Traylor, PJM Weijs… - Current opinion in …, 2018 - journals.lww.com
Insofar as atrophic loss of skeletal muscle mass is concerned, anabolic resistance is a
principal determinant of age-induced losses and appears to be a contributor to critical illness …
principal determinant of age-induced losses and appears to be a contributor to critical illness …