1. Background This document was commissioned to provide a perspective on clinical
registries; to identify specific future opportunities for registries to comprise an informatics …

We review data mining and related computer science techniques that have been studied in
the area of drug safety to identify signals of adverse drug reactions from different data …

Ideally, questions about comparative effectiveness or safety would be answered using an
appropriately designed and conducted randomized experiment. When we cannot conduct a …

Abstract The Patient-Centered Outcomes Research Institute (PCORI) has launched
PCORnet, a major initiative to support an effective, sustainable national research …

Pharmacoepidemiologic and pharmacoeconomic analysis of health care databases has
become a vital source of evidence to support health care decision making and efficient …

Importance The incidence of arterial thromboembolism and venous thromboembolism in
persons with COVID-19 remains unclear. Objective To measure the 90-day risk of arterial …

Abstract The HMO Research Network (HMORN) Virtual Data Warehouse (VDW) is a public,
non-proprietary, research-focused data model implemented at 17 health care systems …

Background International postlicensure studies have identified an increased risk of
intussusception after vaccination with the second-generation rotavirus vaccines RotaTeq …

ABSTRACT The Mini‐Sentinel is a pilot program that is developing methods, tools,
resources, policies, and procedures to facilitate the use of routinely collected electronic …

The scientific community and decision‐makers are increasingly concerned about
transparency and reproducibility of epidemiologic studies using longitudinal healthcare …