MicroRNAs (miRNAs) are fundamental post-transcriptional modulators of several critical
cellular processes, a number of which are involved in host defense mechanisms. In …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

To identify endogenous miRNA-target sites, we isolated AGO-bound RNAs from
Caenorhabditis elegans by individual-nucleotide resolution crosslinking …

miRNAs are small RNAs that guide Argonaute proteins to specific target mRNAs to repress
their translation and stability. Canonically, miRNA targeting is reliant on base pairing of the …

MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways.
These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in …

During microRNA (miRNA) biogenesis, two endonucleolytic reactions convert stem-loop-
structured precursors into mature miRNAs. These processing steps can be …

The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries
in small RNA biology have redefined the biological landscape by significantly altering the …

Two decades after the discovery of the first animal microRNA (miRNA), the number of
miRNAs in animal genomes remains a vexing question. Here, we report findings from …

MicroRNAs (miRNAs) are important non-coding, single-stranded RNAs possessing crucial
regulating roles in human body. Therefore, miRNAs have received extensive attention from …

In normal cells multiple microRNAs (miRNAs) converge to maintain a proper balance of
various processes, including proliferation, differentiation and cell death. miRNA …