Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Given the progressive ageing of Western populations, the fragility fractures market has a
growing socioeconomic impact. Fragility fractures are common in the elderly, negatively …

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects
of physical activity. In particular, irisin has been shown to have beneficial effects in adipose …

Frailty is a complex of symptoms that is characterized by impaired stress tolerance due to a
decline in the functionality of different organs. Due to its multifactorial aetiology, several …

Background Ageing is commonly associated with sarcopenia (SP) and osteoporosis (OP),
both of which are associated with disability, impaired quality of life, and mortality. The aims …

Millions of people worldwide suffer from osteoporosis, which causes bone fragility and
increases the risk of fractures. Osteoporosis is closely related to the inhibition of …

OBJECTIVE We aimed to explore whether frailty was associated with fracture risk and
whether frailty could modify the propensity of type 2 diabetes toward increased risk of …

Background The graded porous structures were designed using triply periodic minimal
surfaces models to mimic the biomechanical properties of bone. The mechanical properties …

Objectives Oral frailty (OF) has been shown to be a predictor of disability. Therefore, it is
important to be able to identify factors associated with OF in order to prevent long-term …

Purpose To describe pre-ICU frailty in critically ill patients using the Clinical Frailty Scale
(CFS). Methods We included patients≥ 18 years admitted to 2 ICUs in Hamilton, Canada …