Metallodrugs are unique: Opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Recent advances in anticancer ruthenium Schiff base complexes

S Parveen - Applied Organometallic Chemistry, 2020 - Wiley Online Library
Nowadays in cancer treatment, both metal complexes and organic molecules are being
widely used. Current years have seen a surge of interest in the application of organometallic …

Metallomacrocycle or 1D chain: Synthesis, structures, and antifungal activities of zinc (II) and silver (I) complexes based on two reduced Schiff base ligands

SX He, HH Yu, C Huang, DM Chen, BX Zhu - Journal of Molecular Structure, 2023 - Elsevier
Two reduced Schiff base ligands (L 1 and L 2) were synthesized from two Schiff base
compounds containing pyridine-2, 6-dicarboxamide skeletons. In the presence of Zn (II) or …

Copper (II) salen-based complexes as potential anticancer agents

N Mohan, CV Vidhya, V Suni, JM Ameer… - New Journal of …, 2022 - pubs.rsc.org
In this work, we have systematically designed and synthesized four Cu (II) salen compounds
(1–4), which have been characterized using various spectroscopic and analytical …

[HTML][HTML] Schiff bases and their metal complexes: Synthesis, structural characteristics and applications

R Meena, P Meena, A Kumari, N Sharma… - Schiff Base in Organic …, 2023 - intechopen.com
The development of Schiff base was a major step forward in the area of coordination
chemistry. Schiff bases, a class of organic compounds, carry the imine or azomethine (> C …

S-benzyldithiocarbazate imine coordinated metal complexes kill Candida albicans by causing cellular apoptosis and necrosis

MA Malik, SA Lone, MY Wani, MIA Talukdar, OA Dar… - Bioorganic …, 2020 - Elsevier
Abstract Development of new chemotherapeutic agents and strategies are urgently needed
to curb and halt the growing menace caused by hard-to-treat microbes. Coordination of …

Synthesis, structural characterization, density functional theory calculations, and antimicrobial, anticancer, and antimetastatic properties of nanosized heteroleptic …

AM Abdallah, NG Zaki, WH Mahmoud… - Applied …, 2021 - Wiley Online Library
In the field of transition metal chemistry, the development of transition metal‐based drugs for
the treatment of diseases such as cancer or microbial infections with minimization of adverse …

[PDF][PDF] Metal Based Bioactive Nitrogen and Oxygen Donor Mono and Bis Schiff Bases: Design, Synthesis, Spectral Characterization, Computational Analysis and …

SH Sumrra, W Zafar, SA Malik, K Mahmood… - Acta Chimica …, 2022 - researchgate.net
The scientific interest in developing the advanced metal based compounds to inhibit and
control bacterial infections is continuously rising. Keeping in view their pharmacological …

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic …

M Woźniczka, M Sutradhar, AJL Pombeiro, M Świątek… - Molecules, 2020 - mdpi.com
The present study describes the coordination properties of a reduced Schiff base, N-(2-
hydroxybenzyl) alanine, towards cobalt (II) using potentiometric as well as spectroscopic …

Unveiling the antifungal mechanisms of CTP, a new copper(II)-theophylline/1,10-phenanthroline complex, on drug-resistant non-albicans Candida species

HF Frota, PF Barbosa, CMA Lorentino, LRF Affonso… - BioMetals, 2024 - Springer
Candida species undeniably rank as the most prevalent opportunistic human fungal
pathogens worldwide, with Candida albicans as the predominant representative. However …