Pathogenic Impact of Fatty Acid-Binding Proteins in Parkinson's Disease—Potential Biomarkers and Therapeutic Targets

I Kawahata, K Fukunaga - International Journal of Molecular Sciences, 2023 - mdpi.com
Parkinson's disease is a neurodegenerative condition characterized by motor dysfunction
resulting from the degeneration of dopamine-producing neurons in the midbrain. This …

Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model

A Cheng, W Jia, DI Finkelstein, N Stefanova… - Acta Pharmacologica …, 2024 - nature.com
Multiple system atrophy (MSA) is a rare, fatal neurodegenerative disease characterized by
the accumulation of misfolded α-synuclein (αSyn) in glial cells, leading to the formation of …

Using fatty acid-binding proteins as potential biomarkers to discriminate between Parkinson's disease and dementia with Lewy bodies: Exploration of a novel …

I Kawahata, T Sekimori, H Oizumi, A Takeda… - International Journal of …, 2023 - mdpi.com
An increase in the global aging population is leading to an increase in age-related
conditions such as dementia and movement disorders, including Alzheimer's disease (AD) …

Feasibility and considerations of epsin2 as a candidate target for multiple system atrophy treatment

A Cheng, B Cai, K Fukunaga, T Sasaki… - Expert Opinion on …, 2023 - Taylor & Francis
Multiple system atrophy (MSA) is a fatal neurodegenerative disease that typically manifests
in adults. It is characterized by progressive autonomic failure, parkinsonism, and indications …

脊髄小脳変性症治療開発update

渡辺宏久, 長尾龍之介, 水谷泰彰, 川畑和也, 伊藤瑞規 - 神経治療学, 2024 - jstage.jst.go.jp
はじめに脊髄小脳変性症 (spinocerebellar ataxia: SCA) は, もっとも治療法が無い神経変性疾患
の 1 つである. しかし, ここ数年, 代表的な孤発性 SCA である多系統萎縮症 (multiple system …