Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

Delirium is the most common manifestation of brain dysfunction in critically ill patients. In the
intensive care unit (ICU), duration of delirium is independently predictive of excess death …

Background To date, 750 000 patients with COVID-19 worldwide have required mechanical
ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We …

The novel coronavirus, SARS-CoV-2-causing Coronavirus Disease 19 (COVID-19),
emerged as a public health threat in December 2019 and was declared a pandemic by the …

Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management
of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design:

Background Delirium is the most common neuropsychiatric syndrome encountered by
clinicians dealing with older adults and the medically ill and is best characterized by 5 core …

With more than 4 million intensive care unit (ICU) admissions per year in the United States,
there is increasing recognition of the long-term consequences of ICU care on the physical …

Postoperative delirium is a geriatric syndrome that manifests as changes in cognition,
attention, and levels of consciousness after surgery. It occurs in up to 50% of patients after …

Dexmedetomidine is a potent, highly selective α-2 adrenoceptor agonist, with sedative,
analgesic, anxiolytic, sympatholytic, and opioid-sparing properties. Dexmedetomidine …

Background Delirium during critical illness results from numerous insults, which might be
interconnected and yet individually contribute to long-term cognitive impairment. We sought …