Paediatric acute liver failure (PALF) is defined as a biochemical evidence of acute liver
injury in a child with no previous history of chronic liver disease characterised by an …

Ornithine transcarbamylase (OTC) deficiency can occur as a severe neonatal-onset disease
in males (but rarely in females) and as a post-neonatal-onset (also known as" late-onset" or …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Background Despite substantial illness burden and healthcare utilization conferred by pain
from vaso-occlusive episodes (VOE) in children with sickle cell disease (SCD), disease …

Ammonia vapor sensors are indispensable for a wide range of applications, from industrial
monitoring to medical diagnosis. However, the development of flexible and standalone …

Extracorporeal blood purification (EBP) techniques provide support for critically ill patients
with single or multiple organ dysfunction. Continuous renal replacement therapy (CRRT) is …

Hyperammonaemia is a metabolic derangement that may cause severe neurological
damage and even death due to cerebral oedema, further complicating the prognosis of its …

Objective Acute liver failure (ALF) is a rare syndrome leading to significant morbidity and
mortality. An important cause of mortality is cerebral edema due to hyperammonemia …

Hyperammonemia occurs frequently in the critically ill but is largely confined to patients with
hepatic dysfunction or failure. Non-hepatic hyperammonemia (NHHA) is far less common …

As survival after pediatric intensive care unit (PICU) admission has improved over recent
years, a key focus now is the reduction of morbidities and optimization of quality of life for …