Recent advance in oxazole-based medicinal chemistry

HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Advances in the synthetic strategies of benzoxazoles using 2-aminophenol as a precursor: an up-to-date review

S Soni, N Sahiba, S Teli, P Teli, LK Agarwal… - RSC advances, 2023 - pubs.rsc.org
Benzoxazole is a resourceful and important member of the heteroarenes that connects
synthetic organic chemistry to medicinal, pharmaceutical, and industrial areas. It is a bicyclic …

A fluorescent dye with large Stokes shift and high stability: synthesis and application to live cell imaging

Z Gao, Y Hao, M Zheng, Y Chen - Rsc Advances, 2017 - pubs.rsc.org
A fluorescent dye, 2, 5-bis (6-amine-benzoxazol-2-yl) thiophene (BBTA), was synthesized by
a two-step reaction from starting material 2, 5-bis (benzoxazol-2-yl) thiophene (BBT). BBTA …

Bimetallic Cooperative Catalysis for Decarbonylative Heteroarylation of Carboxylic Acids via C‐O/C‐H Coupling

C Liu, CL Ji, T Zhou, X Hong, M Szostak - Angewandte Chemie, 2021 - Wiley Online Library
Cooperative bimetallic catalysis is a fundamental approach in modern synthetic chemistry.
We report bimetallic cooperative catalysis for the direct decarbonylative heteroarylation of …

Pd/Cu-Catalyzed C–H/C–H cross coupling of (hetero) arenes with azoles through arylsulfonium intermediates

ZY Tian, ZH Lin, CP Zhang - Organic Letters, 2021 - ACS Publications
A highly efficient method for the selective formal C–H/C–H cross-coupling of azoles and
(hetero) arenes was established through arylsulfonium intermediates under transition-metal …

Palladium metallaphotoredox-catalyzed 2-arylation of indole derivatives

X Wang, X Xun, H Song, Y Liu, Q Wang - Organic Letters, 2022 - ACS Publications
Given that biaryl motifs are found in many useful molecules, including pesticides,
pharmaceuticals, functional materials, and polymers, the development of methods for their …

Synthetically-tailored and nature-derived dual COX-2/5-LOX inhibitors: Structural aspects and SAR

MA Meshram, UO Bhise, PN Makhal, VR Kaki - European Journal of …, 2021 - Elsevier
Inflammation is a most complex pathological process that gives birth to different diseases.
Different inflammatory mediators are released during an inflammation responsible for acute …

Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective

S Chahal, P Rani, Kiran, J Sindhu, G Joshi… - ACS …, 2023 - ACS Publications
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

Palladium catalyzed C sp2–H activation for direct aryl hydroxylation: the unprecedented role of 1, 4-dioxane as a source of hydroxyl radicals

K Seth, M Nautiyal, P Purohit, N Parikh… - Chemical …, 2015 - pubs.rsc.org
A novel strategy for direct aryl hydroxylation via Pd-catalysed Csp2–H activation through an
unprecedented hydroxyl radical transfer from 1, 4-dioxane, used as a solvent, is reported …

Synthesis of benzoxazoles, benzimidazoles, and benzothiazoles using a Brønsted acidic ionic liquid gel as an efficient heterogeneous catalyst under a solvent-free …

TT Nguyen, XTT Nguyen, TLH Nguyen, PH Tran - ACS omega, 2019 - ACS Publications
Herein, we introduce a reusable Brønsted acidic ionic liquid gel (BAIL gel) obtained by
treating 1-methyl-3-(4-sulfobutyl)-1 H-imidazolium hydrogen sulfate with tetraethyl …