Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …

Fibrosis and remodeling of the right ventricle (RV) are associated with RV dysfunction and
mortality of patients with pulmonary hypertension (PH) but it is unknown how much RV …

Despite advances in our understanding of the pathophysiology and the management of
pulmonary arterial hypertension (PAH), significant therapeutic gaps remain for this …

Despite recent therapeutic advances, pulmonary hypertension (PH) remains a fatal disease
due to the development of right ventricular (RV) failure. At present, no treatments targeted at …

Background: Angiotensin II has been implicated in maladaptive right ventricular (RV)
hypertrophy and fibrosis associated with pulmonary hypertension (PH). Natriuretic peptides …

Background: The beneficial effects of parasympathetic stimulation have been reported in left
heart failure, but whether it would be beneficial for pulmonary arterial hypertension (PAH) …

Rationale: Altered pulmonary hemodynamics and fluid flow–induced high shear stress
(HSS) are characteristic hallmarks in the pathogenesis of pulmonary arterial hypertension …

Pulmonary hypertension (PH) is clinically divided into 5 major types, characterized by
elevation in pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) …

Numerous animal models of pulmonary hypertension are currently available. A systematic
review and meta-analysis was performed of a number of experimental studies of disease …

Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung
vasculature characterized by the proliferation of all vascular wall cell types, including …