Simple Summary Prostate cancer is a serious health problem for men around the world, and
it is often caused by inflammation in the prostate gland. The authors of this article explore …

The use of genetically modified animals has been studied in scientific research over time as
a way to discover new treatments or even a cure for various diseases. Transgenic …

Purpose: Inflammatory infiltration plays important roles in both carcinogenesis and
metastasis. We are interested in understanding the inhibitory mechanism of metformin on …

Castration is the standard therapeutic treatment for advanced prostate cancer but with
limited benefit due to the profound relapse and metastasis. Activation of inflammatory …

Neuroendocrine prostate cancer (NEPC) is a more aggressive subtype of castration‐
resistant prostate cancer (CRPC). Although it is well established that PHF8 can enhance …

Goniothalamin (GTN), a natural compound isolated from Goniothalamus species, has
previously demonstrated cytotoxic activity against several cancer cell lines. However …

Piceatannol (PIC), a polyphenol presents in many vegetables and fruits including yellow
passion fruit extract (PFE; Passiflora edulis), has anti-cancer activity, but its molecular targets …

Background In recent times, anti-cancer treatments have focused on Fibroblast Growth
Factor (FGF) and Vascular-Endothelial Growth Factor (VEGF) pathway inhibitors so as to …

The tumor microenvironment offers multiple targets for cancer therapy, including pro-
tumorigenic inflammation. Natural compounds represent an enormous source of new anti …

Delayed cancer progression in the ventral prostate of the Transgenic Adenocarcinoma of the
Mouse Prostate (TRAMP) model has been previously reported upon celecoxib and …