[HTML][HTML] Principles for targeting RNA with drug-like small molecules
KD Warner, CE Hajdin, KM Weeks - Nature reviews Drug discovery, 2018 - nature.com
RNA molecules are essential for cellular information transfer and gene regulation, and
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
RNAs have been implicated in many human diseases. Messenger and non-coding RNAs …
Biochemistry and molecular biology of flaviviruses
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms
Summary Severe-acute-respiratory-syndrome-related coronavirus 2 (SARS-CoV-2) is the
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
positive-sense RNA virus that causes coronavirus disease 2019 (COVID-19). The genome …
N6-methyladenosine in flaviviridae viral RNA genomes regulates infection
The RNA modification N6-methyladenosine (m 6 A) post-transcriptionally regulates RNA
function. The cellular machinery that controls m 6 A includes methyltransferases and …
function. The cellular machinery that controls m 6 A includes methyltransferases and …
Selective 2′-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis
Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) chemistries exploit
small electrophilic reagents that react with 2′-hydroxyl groups to interrogate RNA structure …
small electrophilic reagents that react with 2′-hydroxyl groups to interrogate RNA structure …
Pervasive regulatory functions of mRNA structure revealed by high-resolution SHAPE probing
Summary mRNAs can fold into complex structures that regulate gene expression. Resolving
such structures de novo has remained challenging and has limited our understanding of the …
such structures de novo has remained challenging and has limited our understanding of the …
High-throughput determination of RNA structures
RNA performs and regulates a diverse range of cellular processes, with new functional roles
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells
The 18-kb Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation
during female eutherian mammalian development. Global structural architecture, cell …
during female eutherian mammalian development. Global structural architecture, cell …
Structure mapping of dengue and Zika viruses reveals functional long-range interactions
Abstract Dengue (DENV) and Zika (ZIKV) viruses are clinically important members of the
Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus …
Flaviviridae family with an 11 kb positive strand RNA genome that folds to enable virus …
Coding potential and sequence conservation of SARS-CoV-2 and related animal viruses
In December 2019, a novel human-infecting coronavirus (SARS-CoV-2) was recognized in
China. In a few months, SARS-CoV-2 has caused thousands of disease cases and deaths in …
China. In a few months, SARS-CoV-2 has caused thousands of disease cases and deaths in …