Targeting Macrophage Phenotypes and Metabolism as Novel Therapeutic Approaches in Atherosclerosis and Related Cardiovascular Diseases

J Wang, Q Wu, X Wang, H Liu, M Chen, L Xu… - Current Atherosclerosis …, 2024 - Springer
Purpose of the review Macrophage accumulation and activation function as hallmarks of
atherosclerosis and have complex and intricate dynamics throughout all components and …

The dance of macrophage death: the interplay between the inevitable and the microenvironment

M Makuch, M Stepanechko, M Bzowska - Frontiers in Immunology, 2024 - frontiersin.org
Macrophages are highly plastic cells ubiquitous in various tissues, where they perform
diverse functions. They participate in the response to pathogen invasion and inflammation …

Ligand-dependent interactions between SR-B1 and S1PR1 in macrophages and atherosclerotic plaques

C Bassila, GEG Kluck, N Thyagarajan… - Journal of Lipid …, 2024 - ASBMB
Abstract HDLs carry sphingosine-1-phosphate (S1P) and stimulate signaling pathways in
different cells including macrophages and endothelial cells, involved in atherosclerotic …

Exploration of ferroptosis and necroptosis-related genes and potential molecular mechanisms in psoriasis and atherosclerosis

J Fan, T Zhu, X Tian, S Liu, SL Zhang - Frontiers in Immunology, 2024 - frontiersin.org
Objective Ferroptosis and necroptosis are two recently identified forms of non-apoptotic cell
death. Their dysregulation plays a critical role in the development and progression of …

Apolipoprotein AI: Potential Protection Against Intestinal Injury Induced by Dietary Lipid

JX Wang, SJ Yu, G Huang, YB Yu… - Journal of Inflammation …, 2024 - Taylor & Francis
The intestinal barrier system protects the human body from harmful factors, by continuously
renewing the intestinal epithelium, tight junctions and enteric microbes. However, dietary fat …

Remnant cholesterol is associated with unstable carotid plaque in a neurologically healthy population

W Li, Y Liu, J Liu, Q Guo, J Li, A Wang… - Stroke and Vascular …, 2024 - svn.bmj.com
Background Remnant cholesterol (RC) is considered to be one of the most significant and
important risk factors for atherosclerotic cardiovascular disease (ASCVD). Nonetheless, the …

Bridging the Gap Between the Bench and Bedside: Clinical Applications of High-density Lipoprotein Function

Y Endo, K Sasaki, K Ikewaki - Journal of Atherosclerosis and …, 2024 - jstage.jst.go.jp
Decades of research have reshaped our understanding of high-density lipoprotein (HDL),
shifting our focus from cholesterol (C) levels to multifaceted functionalities. Epidemiological …

Cyclophilin D induces necrotic core formation by mediating mitochondria-associated macrophage death in advanced atherosclerotic lesions

J Koga, R Umezu, Y Kondo, T Shirouzu… - Atherosclerosis, 2024 - Elsevier
Background and aims In advanced atherosclerotic lesions, macrophage deaths result in
necrotic core formation and plaque vulnerability. Cyclophilin D (CypD) is a mitochondria …

High Atherogenic Risk in Ketosis-Prone Type 2 Diabetic Individuals with Ketosis Episodes: A Cross-Sectional Study

X He, Y Luo, J Hao, R Hu, X Yang… - … , Metabolic Syndrome and …, 2023 - Taylor & Francis
Purpose Diabetes is an important contributor to the progression of atherosclerosis (AS). We
aimed to investigate the correlation between ketosis episodes and lipid-related parameters …

Identification of novel prognostic targets in acute kidney injury using bioinformatics and next generation sequencing data analysis

BM Vastrad, CM Vastrad - bioRxiv, 2024 - biorxiv.org
Acute kidney injury (AKI) is a type of renal disease occurs frequently in hospitalized patients,
which may cause abnormal renal function and structure with increase in serum creatinine …