Highlights of the drug-induced liver injury literature for 2021
SM Woo, DM Alhaqqan, DT Gildea… - Expert Review of …, 2022 - Taylor & Francis
ABSTRACT Introduction In 2021, over 3,000 articles on Drug-Induced Liver Injury (DILI)
were published, nearly doubling the annual number compared to 2011. This review selected …
were published, nearly doubling the annual number compared to 2011. This review selected …
Application of high throughput in vitro metabolomics for hepatotoxicity mode of action characterization and mechanistic-anchored point of departure derivation: a case …
S Ramirez-Hincapie, B Birk, P Ternes, V Giri… - Archives of …, 2023 - Springer
Omics techniques have been increasingly recognized as promising tools for Next
Generation Risk Assessment. Targeted metabolomics offer the advantage of providing …
Generation Risk Assessment. Targeted metabolomics offer the advantage of providing …
Model-based translation of DNA damage signaling dynamics across cell types
MM Heldring, LS Wijaya, M Niemeijer… - PLOS Computational …, 2022 - journals.plos.org
Interindividual variability in DNA damage response (DDR) dynamics may evoke differences
in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as …
in susceptibility to cancer. However, pathway dynamics are often studied in cell lines as …
Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
D Yu, J Li, Y Wang, D Guo, X Zhang… - Drug Development …, 2023 - Wiley Online Library
Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell
death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome …
death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome …
FAIR high content screening in bioimaging
The Minimum Information for High Content Screening Microscopy Experiments (MIHCSME)
is a metadata model and reusable tabular template for sharing and integrating high content …
is a metadata model and reusable tabular template for sharing and integrating high content …
[HTML][HTML] N-cadherin Alleviates Apoptosis and Senescence of Nucleus Pulposus Cells via Suppressing ROS-dependent ERS in the Hyper-osmolarity …
L Zou, Y Wang, Y Hu, L Liu, L Luo, Z Chen… - … Journal of Medical …, 2024 - ncbi.nlm.nih.gov
The in-situ osmolarity is an important physicochemical factor that regulates cell fate of
nucleus pulposus cells (NPCs). Our previous studies demonstrated that reduced N-cadherin …
nucleus pulposus cells (NPCs). Our previous studies demonstrated that reduced N-cadherin …
The integrated stress response‐related expression of CHOP due to mitochondrial toxicity is a warning sign for DILI liability
M Vlasveld, G Callegaro, C Fisher, J Eakins… - Liver …, 2024 - Wiley Online Library
Abstract Background and Aims Drug‐induced liver injury (DILI) is one of the most frequent
reasons for failure of drugs in clinical trials or market withdrawal. Early assessment of DILI …
reasons for failure of drugs in clinical trials or market withdrawal. Early assessment of DILI …
Searching for LINCS to Stress: Using Text Mining to Automate Reference Chemical Curation
Adaptive stress response pathways (SRPs) restore cellular homeostasis following
perturbation but may activate terminal outcomes like apoptosis, autophagy, or cellular …
perturbation but may activate terminal outcomes like apoptosis, autophagy, or cellular …
[HTML][HTML] Chemically cross-linked hydrogels from repetitive protein arrays
R Boni, EA Blackburn, DJ Kleinjan, M Jonaitis… - Journal of Structural …, 2023 - Elsevier
Biomaterials for tissue regeneration must mimic the biophysical properties of the native
physiological environment. A protein engineering approach allows the generation of protein …
physiological environment. A protein engineering approach allows the generation of protein …
A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury
LS Wijaya, A Gabor, IE Pot, L van de Have… - Toxicological …, 2024 - academic.oup.com
Drug-induced liver injury (DILI) remains the main reason for drug development attritions
largely due to poor mechanistic understanding. Toxicogenomic to interrogate the …
largely due to poor mechanistic understanding. Toxicogenomic to interrogate the …