Chromosome condensation is a hallmark of mitosis in eukaryotes and is a prerequisite for
faithful segregation of genetic material to daughter cells. Here we show that condensin …

All cellular proteins are synthesized by ribosomes, whose biogenesis in eukaryotes is a
complex multi-step process completed within minutes. Several chemical inhibitors of …

The action of DNA topoisomerase II (Top2) creates transient DNA breaks that are normally
concealed inside Top2-DNA covalent complexes. Top2 poisons, including ubiquitously …

During meiotic prophase, cohesin-dependent axial structures are formed in the
synaptonemal complex (SC). However, the functional correlation between these structures …

ABSTRACT Here, we screened a 10,371 library of diverse molecules using a drug-sensitive
fission yeast strain to identify compounds which cause defects in chromosome segregation …

The CRISPR/Cas9 system, which relies on RNA‐guided DNA cleavage to induce site-
specific DNA double-strand breaks, is a powerful tool for genome editing. This system has …

The cytoskeleton microtubule consists of polymerized αβ-tubulin dimers and plays essential
roles in many cellular events. Reagents that inhibit microtubule behaviors have been …

Fission yeast can be used as a cell-based system for high-throughput drug screening.
However, higher drug concentrations are often needed to achieve the same effect as in …

Many human cancer cells contain more than two centrosomes, yet these cancer cells can
form pseudo-bipolar spindles through the mechanism, called centrosome clustering, and …

In metazoans, the nuclear envelope (NE) breakdown (NEBD) occurs during" open" mitosis
and meiosis. In the fission yeast Schizosaccharomyces pombe, the mitosis and the first …