Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of …

Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

CD34+ cells in human cord blood and marrow are known to give rise to dendritic cells (DC),
as well as to other myeloid lineages. CD34+ cells are rare in adult blood, however, making it …

▪ Abstract The high affinity receptor for immunoglobulin E (designated FcϵRI) is the member
of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific …

The incidence of atopic dermatitis is increasing, and this poses a major burden on health
care costs. A precise understanding of the genetic and immunologic mechanisms is crucial …

We investigated epidermal cell suspensions prepared from lesional and nonlesional atopic
eczema skin, other inflammatory skin conditions, and normal human skin for high-affinity IgE …

Dendritic cells (DC) represent a heterogeneous population of antigen-presenting cells that
are crucial in initiating and shaping immune responses. Although all DC are capable of …

PARASITIC infections are often associated with eosinophilia and high levels of
immunoglobulin E (IgE). This observation has led to speculation that eosinophils and IgE …

IgE and its receptors are believed to have evolved as a mechanism to protect mammals
against parasites. But other and intrinsically innocuous antigens can subvert this system to …

Publisher Summary This chapter focuses on studies of the murine and human leukocyte
FcγR and FCɛR I, with particular reference to the structural characterization of these …