Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in
all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) …

During the generation of a successful adaptive immune response, multiple molecular
signals are required. A primary signal is the binding of cognate antigen to an antigen …

Cancer immunotherapy with immune-checkpoint blockade has improved the outcomes of
patients with various malignancies, yet a majority do not benefit or develop resistance. To …

A genome-wide association scan of∼ 6.6 million genotyped or imputed variants in 882
Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association …

Casitas B cell lymphoma-b (Cbl-b) is a vital negative regulator of TCR and BCR signaling
pathways, playing a significant role in setting an appropriate threshold for the activation of T …

Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a
critical regulator of adaptive immune responses. Cbl-b is essential for establishing the …

CD40 plays a vital role in humoral immunity, via its potent and multifaceted function as an
activating receptor of various immune cells, most notably B lymphocytes. The Epstein‐Barr …

Maintenance of immunological tolerance is a critical hallmark of the immune system. Several
signaling checkpoints necessary to balance activating and inhibitory input to immune cells …

E3 ubiquitin ligases have been placed among the essential molecules involved in the
regulation of T cell functions and T cell tolerance. However, it has never been experimentally …

B lymphocytes produce antibodies under the stimulation of specific antigens, thereby
exerting an immune effect. B cells identify antigens by their surface B cell receptor (BCR) …