Gastrointestinal motility results from coordinated contractions of the tunica muscularis, the
muscular layers of the alimentary canal. Throughout most of the gastrointestinal tract …

▪ Abstract The enteric nervous system exerts local control over mixing and propulsive
movements in the small intestine. When digestion is in progress, intrinsic primary afferent …

The gastrointestinal tract serves the physiological function of digesting and absorbing
nutrients from food and physically mixing and propelling these contents in an oral to anal …

Interstitial cells of Cajal (ICC) are interposed between enteric neurons and smooth muscle
cells in gastrointestinal muscles. The role of intramuscular ICC (IC-IM) in mediating enteric …

The gastrointestinal (GI) tract is innervated by the enteric nervous system (ENS), an
extensive neuronal network that traverses along its walls. Due to local reflex circuits, the …

Interstitial cells of Cajal (ICC) are the pacemakers in gastrointestinal (GI) muscles, and these
cells also mediate or transduce inputs from the enteric nervous system. Different classes of …

The preprotachykinin-A gene-derived peptides substance P and neurokinin (NK) A are
expressed in distinct neural pathways of the mammalian gut. When released from intrinsic …

The tachykinin NK1 receptor is widely distributed in both the central and peripheral nervous
system. In the CNS, NK1 receptors have been implicated in various behavioural responses …

Smooth muscle layers of the gastrointestinal tract consist of a heterogeneous population of
cells that include enteric neurons, several classes of interstitial cells of mesenchymal origin …

For many years morphologists have noted the close relationship between interstitial cells of
Cajal (ICC) and nerve fibers within the tunica muscularis of gastrointestinal (GI) organs …