Abnormalities in mucus production and qualitative properties such as mucus hydration are
central to the pathophysiology of airway disease including cystic fibrosis, asthma, and …

Direct delivery to the lung via inhalation is arguably one of the most logical approaches to
treat lung cancer using drugs. However, despite significant efforts and investment in this …

The mechanisms by which cigarette smoking impairs airway mucus clearance are not well
understood. We recently established a ferret model of cigarette smoke-induced chronic …

Airway mucus obstruction is a key feature of cystic fibrosis (CF) and chronic obstructive
pulmonary disease (COPD). The thin layer of mucus that covers healthy airway surfaces has …

Background Although mucus plugging is a well-reported feature of asthma, whether asthma
and type 2 inflammation affect mucociliary clearance (MCC) is unknown. Research Question …

The story of how we came to use inhaled mannitol to diagnose asthma and to treat cystic
fibrosis began when we were looking for a surrogate for exercise as a stimulus to identify …

Mucociliary clearance (MCC) in CF lung disease is limited by airway dehydration, leading to
persistent bacterial infection and inflammation in the airways. Agents designed to rehydrate …

The solid concentration of pulmonary mucus (wt%) is critical to respiratory health. In patients
with respiratory disease, such as Cystic Fibrosis (CF) and Chronic Obstructive Pulmonary …

Aim: Inhaled hypertonic saline increases mucociliary clearance, improves pulmonary
function, and decreases exacerbations in cystic fibrosis (CF) but contributes to the already …