Multiple-system atrophy is a neurodegenerative disease characterized by progressive
autonomic failure, parkinsonism, and cerebellar and pyramidal tract symptoms. Glial …

Use of selective in-vivo tau imaging will enable improved understanding of tau aggregation
in the brain, facilitating research into causes, diagnosis, and treatment of major tauopathies …

Amyloid fibril is an important pharmaceutical target for diagnostic and therapeutic treatment
of neurodegenerative diseases. However, rational design of chemical compounds that …

The neurodegenerative disorder Alzheimer's disease is characterised by the formation of β-
amyloid plaques and neurofibrillary tangles in the brain parenchyma, which cause synapse …

Neurodegenerative diseases such as Parkinson's disease (PD) are manifested by inclusion
bodies of alpha-synuclein (α-syn) also called α-synucleinopathies. Detection of these …

The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the
characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting …

Protein aggregation within the central nervous system has been recognized as a defining
feature of neurodegenerative diseases since the early 20th century. Since that time, there …

Purpose Deposition of misfolded alpha-synuclein (αSYN) aggregates in the human brain is
one of the major hallmarks of synucleinopathies. However, a target-specific tracer to detect …

ABSTRACT α‐Synucleinopathies including idiopathic Parkinson's disease, dementia with
Lewy bodies and multiple systems atrophy share overlapping symptoms and pathological …

The protein alpha-synuclein (αSYN) plays a central role in synucleinopathies such as
Parkinsons's disease (PD) and multiple system atrophy (MSA). Presently, there are no …