Increased glucose metabolism and uptake are characteristic of many tumors and used
clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor …

One hundred years have passed since Warburg discovered alterations in cancer
metabolism, more than 70 years since Sidney Farber introduced anti-folates that …

In vitro studies have associated oxidative phosphorylation (OXPHOS) with anti-inflammatory
macrophages, whereas pro-inflammatory macrophages rely on glycolysis. However, the …

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is
active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism …

Amino acids are fundamental building blocks supporting life. Their role in protein synthesis
is well defined, but they contribute to a host of other intracellular metabolic pathways …

Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism,
contributing to cellular heterogeneity and disease. Diverse mutations are associated with …

Solid tumors reside in harsh tumor microenvironments (TMEs) together with various stromal
cell types. During tumor progression and metastasis, both tumor and stromal cells undergo …

Impaired redox metabolism is a key contributor to the etiology of many diseases, including
primary mitochondrial disorders, cancer, neurodegeneration and aging. However …

CD4+ T cell differentiation requires metabolic reprogramming to fulfil the bioenergetic
demands of proliferation and effector function, and enforce specific transcriptional …

Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is part of the malate-aspartate
shuttle, a mechanism by which cells transfer reducing equivalents from the cytosol to the …