Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets

Y Zhao, W Xiong, C Li, R Zhao, H Lu, S Song… - … and Targeted Therapy, 2023 - nature.com
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Shine and darkle the blood vessels: Multiparameter hypersensitive MR angiography for diagnosis of panvascular diseases

W Li, J Cheng, C Liu, N Zhang, H Lin, F He, Z Gan… - Science …, 2024 - science.org
Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases.
However, single-modality MRA falls short in diagnosing diverse vascular abnormalities …

NXPH4 mediated by m5C contributes to the malignant characteristics of colorectal cancer via inhibiting HIF1A degradation

L Yang, J Shi, M Zhong, P Sun, X Zhang, Z Lian… - Cellular & Molecular …, 2024 - Springer
Objective Colorectal cancer (CRC) is a form of malignancy that exhibits a comparatively
elevated occurrence and fatality rate. Given the relatively slower progress in diagnostic and …

[HTML][HTML] Mechanisms Controlling the Behavior of Vascular Smooth Muscle Cells in Hypoxic Pulmonary Hypertension: In memory of more than twenty years of …

L Bačáková, A Sedlář, J Musílková… - Physiological …, 2024 - pmc.ncbi.nlm.nih.gov
Pulmonary hypertension is a complex and heterogeneous condition with five main subtypes
(groups). This review focuses on pulmonary hypertension caused by chronic hypoxia …

Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells

Y Fan, D Jialiken, Z Zheng, W Zhang, S Zhang… - Journal of …, 2025 - Elsevier
Abstract Ethnopharmacological relevance Qianyang Yuyin granules (QYYY) have been
used clinically to treat hypertension for over two decades. Previous clinical trials have shown …

Insulin-like growth factor-2 mRNA-binding protein 2 facilitates post-ischemic angiogenesis by increasing the stability of fibroblast growth factor 2 mRNA and its protein …

S Ma, Y Hu, W Xu, W Xiong, X Xu, Y Hou, Y Wang… - Heliyon, 2024 - cell.com
Background Post-ischemic angiogenesis is crucial for reestablishing blood flow in
conditions such as peripheral artery disease (PAD). The role of insulin-like growth factor-2 …

[HTML][HTML] HIF-1α 在高原低氧心肌损伤中的研究进展

杜珂, 祁永福 - Traditional Chinese Medicine, 2024 - hanspub.org
高原心脏损伤(HACI) 是由于高原缺氧引起的常见组织损伤之一, 严重时可危及生命. 研究表明,
缺氧诱导因子-1α (HIF-1α) 是一种氧敏感转录因子, 在缺氧条件下显著增高 …

Enhancing panvascular medicine: unveiling the nexus of pan-cardio-oncology and expanding therapeutic frontiers

Y Hu, Y Zhou, N Dai, S Song, X Zhao… - Science …, 2025 - pubmed.ncbi.nlm.nih.gov
Enhancing panvascular medicine: unveiling the nexus of pan-cardio-oncology and expanding
therapeutic frontiers Enhancing panvascular medicine: unveiling the nexus of …