Since ancient times, humankind has had to struggle against the persistent onslaught of
pathogenic microorganisms. Nowadays, malaria is still the most important infectious disease …

Chemotherapy remains the most important means of controlling malaria, one of the
deadliest infectious parasitic diseases in the world. Antimalarial antifolates have been …

Mutations in Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate
synthase (dhps) genes have been used as means to predict treatment failure to sulfadoxine …

Malaria still poses one of the most serious threats to human health worldwide and the
prevailing lack of effective, clinically licensed, vaccines means that prophylaxis and …

Background Prescription practices have been shown to influence the emergence of anti-
malarial drug resistance. Thus efforts in this study were devoted to evaluating the …

Tetrahydrofolates are essential cofactors for DNA synthesis and methionine metabolism.
Malaria parasites are capable both of synthesizing tetrahydrofolates and precursors de novo …

Background Transient receptor potential vanilloid 2 is a calcium channel activated by
probenecid. Probenecid is a Food and Drug Administration–approved uricosuric drug that …

The targeting of key enzymes in the folate pathway continues to be an effective
chemotherapeutic approach that has earned antifolate drugs a valuable position in the …

Drug combination therapies have been devised to delay the development and spread of
resistant malaria parasites. However, poor design often leads to ineffective combinations …

Malaria and malnutrition remain among the leading causes of death in the developing world,
despite decades of large-scale research and control efforts. Epidemiologically, malaria and …