One of the most exciting developments in the field of biological physics in recent years is the
ability to manipulate single molecules and probe their properties and function. Since its …

Force transmission at integrin-based adhesions is important for cell migration and
mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to …

Fibrous aggregates of Tau protein are characteristic features of Alzheimer disease. We
applied high resolution atomic force and EM microscopy to study fibrils assembled from …

The use of mechanical stresses to induce chemical reactions has attracted significant
interest in recent years. Computational modeling can play a significant role in developing a …

We describe the mechanical behavior of isotropic fibrin networks at the macroscopic scale in
terms of the nanoscale force response of fibrin molecules that are its basic building blocks …

It is now possible to create, in a thin inorganic membrane, a single, sub-nanometer-diameter
pore (ie, a sub-nanopore) about the size of an amino acid residue. To explore the prospects …

Biological silks produced by, for examples, spiders and silkworms exhibit exceptional
mechanical properties, including high strength, toughness, and extensibility, which arise …

The skeleton of many natural and artificial soft materials can be abstracted as networks of
fibers/polymers interacting in a nonlinear fashion. Here, we present a numerical model for …

Sacrificial bonds and hidden length in structural molecules account for the greatly increased
fracture toughness of biological materials compared to synthetic materials without such …

We deduce a fully analytical model to predict the artifacts of the device handles in single
molecule force spectroscopy experiments. As we show, neglecting the handle stiffness can …