Niosomal drug delivery systems for ocular disease—Recent advances and future prospects

S Durak, M Esmaeili Rad, A Alp Yetisgin, H Eda Sutova… - Nanomaterials, 2020 - mdpi.com
The eye is a complex organ consisting of several protective barriers and particular defense
mechanisms. Since this organ is exposed to various infections, genetic disorders, and visual …

Nanotherapies for the treatment of ocular diseases

S Reimondez-Troitiño, N Csaba, MJ Alonso… - European Journal of …, 2015 - Elsevier
The topical route is the most frequent and preferred way to deliver drugs to the eye.
Unfortunately, the very low ocular drug bioavailability (less than 5%) associated with this …

Record ultralarge‐pores, low density three‐dimensional covalent organic framework for controlled drug delivery

Y Zhao, S Das, T Sekine, H Mabuchi… - Angewandte Chemie …, 2023 - Wiley Online Library
The unique structural characteristics of three‐dimensional (3D) covalent organic frameworks
(COFs) like high surface areas, interconnected pore system and readily accessible active …

Betaxolol‐loaded niosomes integrated within pH‐sensitive in situ forming gel for management of glaucoma

A Allam, M Elsabahy, M El Badry, NE Eleraky - International Journal of …, 2021 - Elsevier
Blindness and impaired vision are considered as the most troublesome health conditions
leading to significant socioeconomic strains. The current study focuses on development of …

MOF-based polymeric nanocomposite films as potential materials for drug delivery devices in ocular therapeutics

J Gandara-Loe, BE Souza, A Missyul… - … applied materials & …, 2020 - ACS Publications
Novel MOF-based polymer nanocomposite films were successfully prepared using Zr-based
UiO-67 as a metal–organic framework (MOF) and polyurethane (PU) as a polymeric matrix …

Proniosomes derived niosomes: recent advancements in drug delivery and targeting

M Khatoon, KU Shah, FU Din, SU Shah… - Drug …, 2017 - Taylor & Francis
Vesicular drug delivery systems have gained wide attention in the field of nanotechnology.
Among them proniosomes become the superior over other vesicular carriers. Proniosomes …

Formulation and evaluation of cubosomes drug delivery system for treatment of glaucoma: Ex-vivo permeation and in-vivo pharmacodynamic study

AE Eldeeb, S Salah, M Ghorab - Journal of Drug Delivery Science and …, 2019 - Elsevier
Glaucoma, a chronic disease of elevated intraocular pressure, is considered as the first
leading cause of blindness. Brimonidine tartrate (BRT), a hydrophilic drug with poor ocular …

[HTML][HTML] Nanoparticles in the ocular drug delivery

HY Zhou, JL Hao, S Wang, Y Zheng… - International journal of …, 2013 - ncbi.nlm.nih.gov
Ocular drug transport barriers pose a challenge for drug delivery comprising the ocular
surface epithelium, the tear film and internal barriers of the blood-aqueous and blood-retina …

Metal-organic frameworks, NH2-MIL-88 (Fe), as carriers for ophthalmic delivery of brimonidine

SN Kim, CG Park, BK Huh, SH Lee, CH Min, YY Lee… - Acta Biomaterialia, 2018 - Elsevier
We have proposed a metal-organic framework (MOF), NH 2-MIL-88 (Fe), as a novel carrier
for topical drug delivery to the eye. The NH 2-MIL-88 (Fe) particles were prepared via a …

Doxorubicin hydrochloride-loaded nonionic surfactant vesicles to treat metastatic and non-metastatic breast cancer

M Di Francesco, C Celia, MC Cristiano, N d'Avanzo… - ACS …, 2021 - ACS Publications
Doxorubicin hydrochloride (DOX) is currently used to treat orthotropic and metastatic breast
cancer. Because of its side effects, the use of DOX in cancer patients is sometimes limited; …